KOTOR 2 I think is most anticipated for me right now, though the new Vampire game is looking like it has a little bit of promise to stave off the current slump.
The new Prince of Persia looks HELLA cool. I never played the first one, though I've heard from several sources that it's really addictive. A really underrated game!
But the new one..of man..it looks BADASS. Nothing like cleaving a person in two or using their body as a human shield.
For the record, from the preview video I saw, there looks like there *is* a pretty awesome looking chick running around somewhere...I get the distinct feeling she might be a baddie though.